期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02376
关键词
neutrophils; psoriasis; immunity; respiratory burst; degranulation; neutrophil extracellular traps
类别
资金
- Ministry of Science Technology [MOST 108-2320-B-255-003-MY3, MOST 106-2320-B-255-003-MY3, MOST 104-2320-B-255-004-MY3]
- Ministry of Education [EMRPD1I0441]
- Chang Gung Memorial Hospital [CMRPG5F0161, BMRP450]
Neutrophils are the most abundant innate immune cells. The pathogenic roles of neutrophils are related to chronic inflammation and autoimmune diseases. Psoriasis is a chronic systemic inflammatory disease affecting similar to 2-3% of the world population. The abundant presence of neutrophils in the psoriatic skin lesions serves as a typical histopathologic hallmark of psoriasis. Recent reports indicated that oxidative stress, granular components, and neutrophil extracellular traps from psoriatic neutrophils are related to the initial and maintenance phases of psoriasis. This review provides an overview on the recent (up to 2019) advances in understanding the role of neutrophils in the pathophysiology of psoriasis, including the effects of respiratory burst, degranulation, and neutrophil extracellular trap formation on psoriatic immunity and the clinical relationships.
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