期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 6, 期 2, 页码 1112-1123出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.9b00992
关键词
reinforced fibers; biotextiles; tissue engineering; organ weaving; interpenetrating network hydrogels; skeletal muscles
资金
- National Institutes of Health [R21EB026824, AR066193, EB022403, AR057837, HL137193, GM126831, AR073822]
- Brigham Research Institute Stepping Strong Innovator Award
- National Centre for Research and Development (project START) [STRATEGMED1/233224/10/NCBR/2014]
- NIH through the Organ Design and Engineering Training program [T32 EB16652]
- FCT Fundack para a Ciencia e a Tecnologia [SFRH/BD/96593/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/96593/2013] Funding Source: FCT
Engineering tissue-like scaffolds that can mimic the microstructure, architecture, topology, and mechanical properties of native tissues while offering an excellent environment for cellular growth has remained an unmet need. To address these challenges, multicompartment composite fibers are fabricated. These fibers can be assembled through textile processes to tailor tissue-level mechanical and electrical properties independent of cellular level components. Textile technologies also allow control of the distribution of different cell types and the microstructure of fabricated constructs and the direction of cellular growth within the 3D microenvironment. Here, we engineered composite fibers from biocompatible cores and biologically relevant hydrogel sheaths. The fibers are mechanically robust to being assembled using textile processes and could support adhesion, proliferation, and maturation of cell populations important for the engineering of skeletal muscles. We also demonstrated that the changes in the coating of the multicompartment fibers could potentially enhance myogenesis in vitro.
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