期刊
BMB REPORTS
卷 49, 期 1, 页码 18-25出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2016.49.1.239
关键词
Exosomes; Invasion; Metastasis; Drug resistance; Biomarkers; Therapeutic application
资金
- American Cancer Society [RSG-09-091-01-CSM]
- National Institutes of Health-National Cancer Institute (NIH-NCI) [R01CA163657-01A1]
Recent evidence has indicated that nano-sized vesicles called exosomes mediate the interaction between cancer cells and their microenvironment and play a critical role in the development of cancers. Exosomes contain cargo consisting of proteins, lipids, mRNAs, and microRNAs that can be delivered to different types of cells in nascent as well as distant locations. Cancer cell-derived exosomes (CCEs) have been identified in body fluids such as urine, plasma, and saliva from patients with cancer. Although their content depends on tumor type and stage, CCEs merit consideration as prognostic and diagnostic markers, as vehicles for drug delivery, and as potential therapeutic targets because they could transport various oncogenic elements. In this review, we summarize recent advances regarding the role of CCEs in cancer invasion and metastasis, as well as its potential clinical applications.
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