期刊
BMB REPORTS
卷 49, 期 1, 页码 37-44出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2016.49.1.185
关键词
Function; Isoform; MACF1; Structure; Spectraplakin
资金
- National Natural Science Foundation of China [31400725, 31570940]
- China Postdoctoral Science Foundation [2014M562450, 2015T81051]
- Natural Science Basic Research Plan in Shaanxi Province of China [2015JQ3076]
- Fundamental Research Funds for the Central Universities [3102014JKY15007]
Spectraplakins are crucially important communicators, linking cytoskeletal components to each other and cellular junctions. Microtubule actin crosslinking factor 1 (MACF1), also known as actin crosslinking family 7 (ACF7), is a member of the spectraplakin family. It is expressed in numerous tissues and cells as one extensively studied spectraplakin. MACF1 has several isoforms with unique structures and well-known function to be able to crosslink F-actin and microtubules. MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years. Here, we summarize the current knowledge on the presence and function of MACF1 and provide perspectives on future research of MACF1 based on our studies and others.
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