期刊
NANOMATERIALS
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/nano9101489
关键词
manganese and zinc ferrite magnetic nanoparticles; ethylene glycol; polyol method; magnetic hyperthermia; specific absorption rate; cancer cell uptake; endocytosis; cytotoxicity; biodegradation
类别
资金
- Romanian National Authority for Scientific Research, CNCSIS-UEFISCDI [PN-III-P1-1.1-TE-2016-0967, PN-III-P4-ID-PCCF-2016-0112]
Manganese and zinc ferrite magnetic nanoparticles (MNPs) were successfully synthesized using the polyol method in ethylene glycol and were found to have high saturation magnetization values (90-95 emu/g at 4 K) when formed by similar to 30-nm crystallites assembled in an similar to 80-nm multicore structure. Hyperthermia data revealed a sigmoidal dependence of the specific absorption rate (SAR) on the alternating magnetic field (AMF) amplitude, with remarkable saturation SAR values in water of similar to 1200 W/g(Fe+Mn) and similar to 800 W/g(Fe+Zn) for the Mn and Zn ferrites, respectively. The immobilization of the MNPs in a solid matrix reduced the maximum SAR values by similar to 300 W/g(Fe+Mn, Zn) for both ferrites. The alignment of the MNPs in a uniform static magnetic field, before their immobilization in a solid matrix, significantly increased their heating performance. Toxicity assays performed in four cell lines revealed a lower toxicity for the Mn ferrites, while in the case of the Zn ferrites, only similar to 50% of cells were viable upon their incubation for 24 h with 0.2 mg/mL of MNPs. Cellular uptake experiments revealed that both MNPs entered the cells in a time-dependent manner, as they were found initially in endosomes and later in the cytosol. All of the studied cell lines were more sensitive to the ZnFe2O4 MNPs.
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