期刊
BMB REPORTS
卷 49, 期 5, 页码 293-296出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2016.49.5.023
关键词
Contact hypersensitivity; ILC10; Innate lymphoid cells (ILCs); Interleukin-10; regulatory ILCs
资金
- National Research Foundation of Korea (NRF) grant - Korean government (MSIP) [NRF-2013-R1A4A1069575]
- National Research Foundation of Korea (MSIP) [NRF-2012R1A2A1A03670516, NRF-2013R1A1A2058984]
The immunoregulatory cytokine Interleukin 10 (IL-10) protein is produced by various cells during the course of inflammatory disorders. Mainly, it downregulates pro-inflammatory cytokines, antigen presentation, and helper T cell activation. In this study, we show that the ratio of IL-10-producing cells was significantly increased in lineage negative (i.e., not T, B, or leukocyte cell lineages) cells than in lineage positive cells in lymphoid and peripheral tissues. We further observed that IL-10-producing innate lymphoid cells (ILCs), here called firstly ILC10, were increased in number in oxazolone-induced contact hypersensitivity (CHS) mice. In detail, IL-10-producing lineage negative cells were elevated in the axillary, inguinal lymph node, and ear tissues of CHS mice. Notably, the cells expressed classical ILC marker proteins such as CD45, CD127, and Sca-1. Altogether, our findings suggest for the first time that ILC10s are present in various physiological settings and could be involved in numerous immune responses as regulatory cells.
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