期刊
MOLECULAR THERAPY-NUCLEIC ACIDS
卷 19, 期 -, 页码 405-412出版社
CELL PRESS
DOI: 10.1016/j.omtn.2019.11.022
关键词
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资金
- National Natural Science Foundation of China [81701019, 81870763]
- Tianjin Science and Technology Commission General Project [18JCYBJC92400]
- Tianjin Stomatology Hospital Doctor/Master Key Project [2019BSZD06]
N6-methyladenosine (m(6)A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m(6)A modifications of RNA regulate splicing, translocation, stability, and translation into proteins. m(6)A modifications are catalyzed by RNA methyltransferases, such as METTL3, METTL14, and WTAP (writers); the modifications are removed by the demethylases fat mass and obesity-associated protein (FTO) and ALKBH5 (ALKB homolog 5) (erasers); and the modifications are recognized by m(6)A-binding proteins, such as YTHDF domain-containing proteins and IGF2BPs (readers). Abnormal changes in the m(6)A levels of these genes are closely related to tumor occurrence and development. In this paper, we review the role of m 6 A in human cancer and summarize its prospective applications in cancer.
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