期刊
BIOPHYSICAL JOURNAL
卷 108, 期 4, 页码 863-871出版社
CELL PRESS
DOI: 10.1016/j.bpj.2014.12.018
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类别
资金
- Spanish Ministry of Economy [BFU 2011-28566, BFU 2012-36241, BIO 2013-42978-P]
- Basque Government [IT 838-13, IT 849-13]
- Basque Government
In a previous article, we demonstrated that histones (H1 or histone octanners) interact with negatively charged bilayers and, induce extensive aggregation of vesicles containing phosphatidylinositol-4-phosphate (PlP) and, to a lesser extent, vesicles containing phosphatidylinositol (Pl). Here, we found that vesicles containing PIP, but not those containing PI, can undergo fusion induced by histones. Fusion was demonstrated through the observation of intervesicular mixing of total lipids and inner monolayer lipids, and by ultrastructural and confocal microscopy studies. Moreover, in both Pl- and PlP-containing vesicles, histones caused permeabilization and release of vesicular aqueous contents, but the leakage mechanism was different (all-or-none for PI and graded release for PIP vesicles). These results indicate that histones could play a role in the remodeling of the nuclear envelope that takes place during the mitotic cycle.
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