期刊
MICROMACHINES
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/mi10110787
关键词
collagen; platelet; thrombus
类别
资金
- European Union's Horizon 2020 research and innovation program under Marie Sklodowska-Curie grant [766118]
- Interreg V Euregio Meuse-Rhine, Poly-Valve
Microfluidic assays are versatile tests which, using only small amounts of blood, enable high throughput analyses of platelet function in several minutes. In combination with fluorescence microscopy, these flow tests allow real-time visualisation of platelet activation with the possibility of examining combinatorial effects of wall shear rate, coagulation and modulation by endothelial cells. In particular, the ability to use blood and blood cells from healthy subjects or patients makes this technology promising, both for research and (pre)clinical diagnostic purposes. In the present review, we describe how microfluidic devices are used to assess the roles of platelets in thrombosis and haemostasis. We place emphasis on technical aspects and on experimental designs that make the concept of blood-vessel-component-on-a-chip an attractive, rapidly developing technology for the study of the complex biological processes of blood coagulability in the presence of flow.
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