期刊
BIOPHYSICAL JOURNAL
卷 109, 期 7, 页码 1321-1329出版社
CELL PRESS
DOI: 10.1016/j.bpj.2015.08.016
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资金
- Ministry of Education of Singapore, National Research Foundation of Singapore [MOE 2013-T2-1-154]
- Research Centre of Excellence Grant in Mechanobiology from the Ministry of Education, Singapore
- [VA 5IO1BX000372]
A set of abundant nucleoid-associated proteins (NAPs) play key functions in organizing the bacterial chromosome and regulating gene transcription globally. Histone-like nucleoid structuring protein (H-NS) is representative of a family of NAPs that are widespread across bacterial species. They have drawn extensive attention due to their crucial function in gene silencing in bacterial pathogens. Recent rapid progress in single-molecule manipulation and imaging technologies has made it possible to directly probe DNA binding by H-NS, its impact on DNA conformation and topology, and its competition with other DNA-binding proteins at the single-DNA-molecule level. Here, we review recent findings from such studies, and provide our views on how these findings yield new insights into the understanding of the roles of H-NS family members in DNA organization and gene silencing.
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