期刊
JOURNAL OF DIABETES RESEARCH
卷 2019, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2019/6053604
关键词
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资金
- Chinese National Natural Science Foundation [81770792]
- Capital Funds for Health Improvement and Research [2018-4-2034]
- Capital Clinical Research Foundation of Beijing Municipal Science and Technology Commission [Z161100000516069]
Aims/Introduction. This study is aimed at (1) investigating the change of beta-cell dysfunction as baseline fasting glucose progresses in newly diagnosed patients with T2DM and (2) finding whether body mass index (BMI) has different degrees of impact on insulin secretion as baseline fasting glucose progresses. Materials and Methods. 661 patients with newly diagnosed T2DM were enrolled in the present study. A 75g oral glucose tolerance test was used to calculate HOMA-beta, HOMA-IR, early-phase insulin secretion index (EISI, calculated as Delta I-30/Delta G(30)), and area under the insulin releasing curve (AUC(I0-180)). Patients were divided into low, medium, and high FBG groups. Each group was further divided into lean, overweight, and obese subgroups according to BMI. Results. A decrease of EISI and HOMA-beta and an increase of HOMA-IR were shown among different FBG groups significantly. In the medium FBG group, AUC(I0-180), EISI, HOMA-beta, and HOMA-IR in obese patients were higher than those in lean and overweight patients. In the low and high FBG groups, AUC(I0-180), HOMA-beta, and HOMA-IR in obese patients were higher than those in other subgroups. BMI was positively associated with high EISI in the medium FBG group but failed to yield a significant association with EISI in the low and high FBG groups. Conclusions. During the progression of baseline FBG, beta-cell dysfunction and insulin resistance worsened. As FBG increased, increased BMI had a positive influence on beta-cell dysfunction in all FBG groups. The independent factors that correlated to EISI differed with the increasing of baseline FBG.
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