4.5 Article

Synthesis of Phosphoryl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones from 2-Arylbenzoimidazoles and Diarylphosphine Oxides

期刊

ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 8, 期 11, 页码 2042-2045

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201900570

关键词

Radical Cyclization Reaction; Phosphorylation; Silver-catalyzed; Benzimidazo[2; 1-a]isoquinolin-6(5H)-ones

资金

  1. National Natural Science Foundation of China [21501010, 21971224]
  2. China Postdoctoral Science Foundation [2019M652561]
  3. Key Research Projects of Universities in Henan Province [19A350011, 20A150006]
  4. Henan Province Young Talents Elevation Program [2019HYTP023]
  5. Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation [2019CL03]

向作者/读者索取更多资源

An efficient and convenient silver-catalyzed procedure was developed for the synthesis of various phosphoryl-substituted benzimidazo[2,1-a]isoquinoline-6(5H)-ones from diarylphosphine oxides and 2-arylbenzoimidazoles. Moreover, the phosphoryl-substituted indolo[2,1-a]isoquinolin-6(5H)-ones could also be achieved by using this strategy under mild reaction conditions in the presence of AgNO3/K2S2O8.

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