期刊
PLOS NEGLECTED TROPICAL DISEASES
卷 13, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0007733
关键词
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资金
- United States Department of Defense, Defense Threat Reduction Agency, Broad Agency Announcement grant [HDTRA1-17-1-0028]
- Department of Atomic Energy, Government of India [2012/21/06/BRNS]
- Biological Defense Research Directorate of the Naval Medical Research Center [HT9404-13-1-0021]
- Component Project: Soluble Trimeric Filovirus Envelope Glycoproteins
Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission. We present evidence for prior exposure of bat harvesters and two resident fruit bat species to filovirus surface glycoproteins by screening sera in a multiplexed serological assay. Antibodies reactive to two antigenically distinct filoviruses were detected in human sera and to three individual filoviruses in bats in remote Northeast India. Sera obtained from Eonycteris spelaea bats showed similar patterns of cross-reactivity as human samples, suggesting them as the species responsible for the spillover. In contrast, sera from Rousettus leschenaultii bats reacted to two different virus glycoproteins. Our results indicate circulation of several filoviruses in bats and the possibility for filovirus transmission from bats to humans.
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