期刊
OPEN BIOLOGY
卷 9, 期 10, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.190155
关键词
actin; bending penalty; alignment; geometry; gene expression; soft matter physics
资金
- NIH [HL137232]
- Center for Engineering MechanoBiology, a National Science Foundation Science and Technology Center [CMMI 1548571]
The vast majority of cell biological studies examine function and molecular mechanisms using cells on flat surfaces: glass, plastic and more recently elastomeric polymers. While these studies have provided a wealth of valuable insight, they fail to consider that most biologically occurring surfaces are curved, with a radius of curvature roughly corresponding to the length scale of cells themselves. Here, we review recent studies showing that cells detect and respond to these curvature cues by adjusting and re-orienting their cell bodies, actin fibres and nuclei as well as by changing their transcriptional programme. Modelling substratum curvature has the potential to provide fundamental new insight into cell behaviour and function in vivo.
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