期刊
G3-GENES GENOMES GENETICS
卷 10, 期 1, 页码 401-415出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.119.400780
关键词
male mate choice; pheromones; courtship behavior; reproductive isolation; behavioral genetics
资金
- Howard Hughes Medical Institute through the Science Education Program
- National Institutes of Health [R01 GM098614]
- Cornell Drosophila Stock Center [CSBR 1820594]
- Bloomington Drosophila stock center [NIH P400D018537]
Species of flies in the genus Drosophila differ dramatically in their preferences for mates, but little is known about the genetic or neurological underpinnings of this evolution. Recent advances have been made to our understanding of one case: pheromone preference evolution between the species D. melanogaster and D. simulans. Males of both species are very sensitive to the pheromone 7,11-HD that is present only on the cuticle of female D. melanogaster. In one species this cue activates courtship, and in the other it represses it. This change in valence was recently shown to result from the modification of central processing neurons, rather than changes in peripherally expressed receptors, but nothing is known about the genetic changes that are responsible. In the current study, we show that a 1.35 Mb locus on the X chromosome has a major effect on male 7,11-HD preference. Unfortunately, when this locus is divided, the effect is largely lost. We instead attempt to filter the 159 genes within this region using our newfound understanding of the neuronal underpinnings of this phenotype to identify and test candidate genes. We present the results of these tests, and discuss the difficulty of identifying the genetic architecture of behavioral traits and the potential of connecting these genetic changes to the neuronal modifications that elicit different behaviors.
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