期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201900626
关键词
neuromuscular junctions; skeletal muscle regeneration; tissue engineering; vascularization; volumetric muscle loss
资金
- NIH (NIAMS NRSA F31)
- Maryland Stem Cell Research Fund [2016-MSCRFI-2692]
Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising solution for VML treatment and significant research has been performed using tissue engineered muscle constructs in preclinical models of VML with a broad range of defect locations and sizes, tissue engineered construct characteristics, and outcome measures. Due to the complex vascular and neural anatomy within skeletal muscle, regeneration of functional vasculature and nerves is vital for muscle recovery following VML injuries. This review aims to summarize the current state of the field of skeletal muscle tissue engineering using 3D constructs for VML treatment with a focus on studies that have promoted vascular and neural regeneration within the muscle tissue post-VML.
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