期刊
ADVANCED HEALTHCARE MATERIALS
卷 8, 期 23, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201900974
关键词
colorectal cancer; endoscopy; fluorescence; molecular imaging; the second near-infrared window
资金
- Natural Science Foundation of China [81402043, 81201141]
- Clinical Capability Construction Project for Liaoning Provincial Hospitals [LNCCC-D50-2015, LNCCC-C09-2015]
- China postdoctoral science foundation [2016T90233]
Endoscopy is a clinical gold standard to exam the interior of a hollow organ or body cavity. For the first of time, this study presents the design and construction of a fluorescent endoscopic system that harnesses the power of the second near-infrared window II (NIR-II) fluorescence imaging. An NIR-II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR-II endoscopy imaging system. Simultaneous NIR-II fluorescence and white-light (WL) imaging of VEGF is validated in an orthotopic rat colorectal cancer model. This NIR-II endoscopy system is a generalizable design, and it is compatible with the most of current clinic endoscopies. Similar hardware upgrades are expected to greatly promote the application of NIR-II fluorescent imaging in the clinic.
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