期刊
ADVANCED HEALTHCARE MATERIALS
卷 8, 期 21, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201900968
关键词
gut models; human intestine; inflammatory bowel disease; intestine-on-a-chip; microfluidics
资金
- Australian Research Council [IC140100026] Funding Source: Australian Research Council
- Australian Research Council [IC140100026, DP 270102931] Funding Source: Medline
- University of Sydney for establishing Centre for Advanced Food Enginomics Funding Source: Medline
Models of the human gastrointestinal tract (GIT) can be powerful tools for examining the biological interactions of food products and pharmaceuticals. This can be done under normal healthy conditions or using models of disease-many of which have no curative therapy. This report outlines the field of gastrointestinal modeling, with a particular focus on the intestine. Traditional in vivo animal models are compared to a range of in vitro models. In vitro systems are elaborated over time, recently culminating with microfluidic intestines-on-chips (IsOC) and 3D bioengineered models. Macroscale models are also reviewed for their important contribution in the microbiota studies. Lastly, it is discussed how in silico approaches may have utility in predicting and interpreting experimental data. The various advantages and limitations of the different systems are contrasted. It is posited that only through complementary use of these models will salient research questions be able to be addressed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据