期刊
TRAVEL MEDICINE AND INFECTIOUS DISEASE
卷 33, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tmaid.2019.101521
关键词
Asia; Hotel; Multi-drug resistance; Pre-travel advice; Risk factor analysis
资金
- Bundesministerium fur Bildung und Forschung (BMBF) as part of the project Rationaler Antibiotikaeinsatz durch Information und Kommunikation: Ein multimediales Modellprojekt mit kontrolliertem Design (RAI) - InfectControl 2020 programme [03ZZ0804D]
- European Commission [2014/344-660]
- European Programme for Intervention Epidemiology Training, European Centre for Disease Prevention and Control
Background: Intercontinental travel contributes to the spread of extended-spectrum beta-lactamase producing Enterobacterales (ESBL-PE). We assessed risk factors for intestinal ESBL-PE colonization in people travelling to low and middle income countries in the tropics and subtropics to better understand how travel affects ESBL-PE spread. Method: This prospective cohort study in travellers attending a travel clinic in Leipzig, Germany was conducted in 2016-2017. Information on risk factors related to travel, symptoms, antibiotic use, health care usage, accommodation, destination, diet and hygiene was collected by questionnaire after travel. Stools were phenotypically tested for ESBL-PE before and after travel. Risk factors for ESBL-PE colonization were identified using logistic regression. Results: Of the 230 travellers that were ESBL-PE negative before travelling, 23% (n = 53) travellers returned positive. Multivariable analyses showed that age, type of accommodation and travelling to Asia were associated with ESBL-PE colonization. Conclusions: Given that a considerable amount of travellers returned with ESBL-PE, we recommend raising awareness in returning high-risk travellers, e.g. those returning from high-risk areas. They should be aware that they may carry antimicrobial-resistant bacteria after travel, and how they can prevent its spread. The role of the type of accommodation as a factor favouring intestinal colonization with ESBL-PE requires further investigation.
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