期刊
STEM CELL RESEARCH & THERAPY
卷 10, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13287-019-1484-6
关键词
Mesenchymal stem; stromal cells; Extracellular vesicles; Exosomes; Microvesicles; Functional proteins
资金
- Natural Science Foundation of Zhejiang Province [LYY18H310008, LGF18H150007]
- National Natural Science Foundation of China [81671956, 81570071, 81772122]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents [2016-6]
Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine factors and MSC-derived EVs (MSC-EVs). Recent studies suggest that MSC-EVs may serve as a novel and cell-free alternative to whole-cell therapies. The focus of this review is to discuss the functional proteins which facilitate the effects of MSC-EVs. The first section of the review discusses the general functions of EV proteins. Next, we describe the proteomics of MSC-EVs as compared with their parental cells. Then, the review presents the current knowledge that protein contents of MSC-EVs play an essential role in immunomodulation and treatment of various diseases. In summary, functional protein components are at least partially responsible for disease-modulating capacity of MSC-EVs.
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