期刊
SCIENTIFIC REPORTS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-019-47918-7
关键词
-
资金
- Spanish Ministry of Economy and Competitiveness via the Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III [PI13/01393]
- European Regional Development Funds (ERDF)
- Spanish Ministry of Education [FPU13/04365, FPU14/04172]
- Fundacion Iberoamericana de Nutricion (FINUT)
- Redes Tematicas de Investigacion Cooperativa RETIC [Red SAMID RD16/0022]
- AstraZeneca HealthCare Foundation
- University of Granada Plan Propio de Investigacion
- Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades (ERDF) [SOMM17/6107/UGR]
- Retos de la Sociedad [DEP2016-79512-R]
Humans have metabolically active brown adipose tissue (BAT). However, what is the relation between exercise or physical activity with this tissue remains controversial. Therefore, the main aim of the present study is to examine whether cardiorespiratory fitness and muscular strength are associated with brown adipose tissue (BAT) volume and activity after exposure to cold in young, sedentary adults. Cardiorespiratory fitness was determined in 119 young, healthy, sedentary adults (68% women, age 21.9 +/- 2.1 years, body mass index 25 +/- 4.8 kg/m(2)) via the maximum treadmill exercise test, and their muscular strength assessed by the handgrip strength test and the 1-repetition maximum bench and leg press tests. Some days later, all subjects were exposed to 2 h of personalized exposure to cold and their cold-induced BAT volume and activity determined by a combination of F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography and computed tomography scan. Cardiorespiratory fitness was associated with neither the BAT volume nor BAT activity (P >= 0.05). However, handgrip strength with respect to lean body mass was positively (though weakly) associated with BAT activity as represented by the F-18-FDG mean standardised uptake value (SUV) (beta = 3.595, R-2 = 0.039, P = 0.031) and SUVpeak value (beta = 15.314, R-2 = 0.037, P = 0.035). The above relationships remained after adjusting for several confounders. No other associations were found. Handgrip strength with respect to lean body mass is positively associated with BAT activity (SUVmean and SUVpeak) in young adults after exposure to cold - but only weakly. Further studies are needed to reveal the relationship between muscular fitness and human BAT characteristics.
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