期刊
NUTRIENTS
卷 11, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/nu11122890
关键词
miRNAs; childhood obesity; biomarkers
资金
- Spanish Ministry of Industry and Competitiveness [DEP2016-78377-R]
- European Regional Development Fund (ERDF)
- Spanish Ministry of Economy and Competitiveness [BES-2017-080770]
- University of Granada
- UGR Research and Knowledge Transfer Fund (PPIT) 2016
- Excellence Actions Programme
- Excellence Actions Programe
Early detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142-3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions.
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