期刊
NUTRIENTS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nu11091988
关键词
bitter orange; obesity; adipogenesis; thermogenesis; AMP-activated protein kinase
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [NRF-2015R1A4A1042399, 2017M3A9E4065333, 2018R1D1A1B07049882]
- National Research Foundation of Korea [2018R1D1A1B07049882, 2017M3A9E4065333] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Obesity is a global health threat. Herein, we evaluated the underlying mechanism of anti-obese features of bitter orange (Citrus aurantium Linne, CA). Eight-week-administration of CA in high fat diet-induced obese C57BL/6 mice resulted in a significant decrease of body weight, adipose tissue weight and serum cholesterol. In further in vitro studies, we observed decreased lipid droplets in CA-treated 3T3-L1 adipocytes. Suppressed peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT/enhancer binding protein alpha indicated CA-inhibited adipogenesis. Moreover, CA-treated primary cultured brown adipocytes displayed increased differentiation associated with elevation of thermogenic factors including uncoupling protein 1 and PPAR gamma coactivator 1 alpha as well. The effects of CA in both adipocytes were abolished in AMP-activated protein kinase alpha (AMPK alpha)-suppressed environments, suggesting the anti-adipogenic and pro-thermogenic actions of CA were dependent on AMPK alpha pathway. In conclusion, our results suggest CA as a potential anti-obese agent which regulates adipogenesis and thermogenesis via AMPK alpha.
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