期刊
ACS CATALYSIS
卷 10, 期 1, 页码 36-42出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b04038
关键词
alkyl ketones; carbonylation; CO; nickel; secondary aliphatic electrophiles
资金
- National Natural Science Foundation of China [21425208, 21672238, 21421002]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
The nickel-catalyzed carbonylation of aliphatic electrophiles with the most straightforward CO remains challenging. Here, we describe an example of the nickel-catalyzed carbonylation of secondary alkyl halides with arylboronic acids under 1 atm of CO. The reaction exhibits high functional group tolerance and a broad substrate scope, including trifluoromethylated, difluoromethylated, and difluoroacetylated secondary alkyl iodides and secondary benzyl bromides, providing a general and cost-efficient method to access alkyl ketones, especially alpha-trifluoromethylated alkyl ketones that are of great interest in medicinal chemistry. Preliminary mechanistic studies reveal that a bimetallic oxidative addition is likely involved in the reaction.
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