期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-13142-0
关键词
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资金
- National Key Basic Research Program of China [2017YFA0504000, 2016YFA0500403]
- National Science Foundation of China [31670039, 31970058, 8182780030, 31821091]
- NIH [5R01NS087198, 5R01NS047325, 1R21AG061751]
Mitochondrial calcium ([Ca2+](mito)) dynamics plays vital roles in regulating fundamental cellular and organellar functions including bioenergetics. However, neuronal [Ca2+](mito) dynamics in vivo and its regulation by brain activity are largely unknown. By performing twophoton Ca2+ imaging in the primary motor (M1) and visual cortexes (V1) of awake behaving mice, we find that discrete [Ca2+](mito) transients occur synchronously over somatic and dendritic mitochondrial network, and couple with cytosolic calcium ([Ca2+](cyto)) transients in a probabilistic, rather than deterministic manner. The amplitude, duration, and frequency of [Ca2+](cyto) transients constitute important determinants of the coupling, and the coupling fidelity is greatly increased during treadmill running (in M1 neurons) and visual stimulation (in V1 neurons). Moreover, Ca2+/calmodulin kinase II is mechanistically involved in modulating the dynamic coupling process. Thus, activity-dependent dynamic [Ca2+](mito)-to[Ca2+] cyto coupling affords an important mechanism whereby [Ca2+](mito) decodes brain activity for the regulation of mitochondrial bioenergetics to meet fluctuating neuronal energy demands as well as for neuronal information processing.
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