期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-13118-0
关键词
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资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES
- Brasilia, Brazil)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG
- Belo Horizonte, Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq
- Brasilia, Brazil)
- RCUK Newton Institutional Link Funding [172629373]
- BBSRC [BB/L026716/1, BB/L026716/2] Funding Source: UKRI
Infections caused by multidrug resistant bacteria represent a therapeutic challenge both in clinical settings and in livestock production, but the prevalence of antibiotic resistance genes among the species of bacteria that colonize the gastrointestinal tract of ruminants is not well characterized. Here, we investigate the resistome of 435 ruminal microbial genomes in silico and confirm representative phenotypes in vitro. We find a high abundance of genes encoding tetracycline resistance and evidence that the tet(W) gene is under positive selective pressure. Our findings reveal that tet(W) is located in a novel integrative and conjugative element in several ruminal bacterial genomes. Analyses of rumen microbial metatranscriptomes confirm the expression of the most abundant antibiotic resistance genes. Our data provide insight into antibiotic resistange gene profiles of the main species of ruminal bacteria and reveal the potential role of mobile genetic elements in shaping the resistome of the rumen microbiome, with implications for human and animal health.
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