期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-12908-w
关键词
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资金
- Max Planck Society
- German Research Foundation (DFG) [CRC 1127]
- DFG under Germany's excellence strategy [EXC 2051, 390713860]
- Katholischer Akademischer Auslanderdienst (KAAD)
- LOEWE - government of Hessen
Flagellated oomycetes frequently infect unicellular algae, thus limiting their proliferation. Here we show that the marine oomycete Lagenisma coscinodisci rewires the metabolome of the bloom-forming diatom Coscinodiscus granii, thereby promoting infection success. The algal alkaloids beta-carboline and 4-carboxy-2,3,4,9-tetrahydro-1H-beta-carboline are induced during infection. Single-cell profiling with AP-MALDI-MS and confocal laser scanning microscopy reveals that algal carbolines accumulate in the reproductive form of the parasite. The compounds arrest the algal cell division, increase the infection rate and induce plasmolysis in the host. Our results indicate that the oomycete manipulates the host metabolome to support its own multiplication.
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