期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-11707-7
关键词
-
资金
- U.K. Medical Research Council [SNCF G1002055, MR/P012418/1, ERA-NET NEURON MR/R005532/1]
- International Spinal Research Trust [CHASE-IT II_02]
- National Institutes of Health [2 R01 GM 093627-05]
- Rosetrees Trust [A1384]
- MRC [MR/P012418/1, G1002055, MR/R005532/1] Funding Source: UKRI
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally referred to as a glial scar, the spinal injury scar in fact comprises multiple cellular and extracellular components. This multidimensional nature should be considered when aiming to understand the role of scarring in limiting tissue repair and recovery. In this Review we discuss recent advances in understanding the composition and phenotypic characteristics of the spinal injury scar, the oversimplification of defining the scar in binary terms as good or bad, and the development of therapeutic approaches to target scar components to enable improved functional outcome after spinal cord injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据