期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-11862-x
关键词
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资金
- National Health and Medical Research Council of Australia (NHMRC) [APP1045783, 628434, ID400413, ID400281]
- Peter MacCallum Cancer Foundation
- Australian Cancer Research Foundation
- Australian Ovarian Cancer Study Group
- U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- Cancer Council Victoria
- Queensland Cancer Fund
- Cancer Council New South Wales
- Cancer Council South Australia
- Cancer Council Tasmania
- Cancer Foundation of Western Australia
- Ovarian Cancer Australia
- Peter MacCallum Foundation
- Terry Fox Research Institute
- National Health and Medical Research Council [ID 310670, ID 628903]
- Cancer Institute NSW [12/RIG/1-17, 15/RIG/1-16]
- BC Cancer Foundation
- VGH and UBC Hospital Foundation
- National Institutes of Health [R01-CA122443, P30-CA15083, P50CA136393]
- Mayo Foundation
- Minnesota Ovarian Cancer Alliance
- Fred C. and Katherine B. Andersen Foundation
- Nicola Murray Foundation
Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progression, high-grade and metastatic disease are poorly defined. We perform genetic analysis of MOC across all histological grades, including benign and borderline mucinous ovarian tumors, and compare these to tumors from other potential extra-ovarian sites of origin. Here we show that MOC is distinct from tumors from other sites and supports a progressive model of evolution from borderline precursors to high-grade invasive MOC. Key drivers of progression identified are TP53 mutation and copy number aberrations, including a notable amplicon on 9p13. High copy number aberration burden is associated with worse prognosis in MOC. Our data conclusively demonstrate that MOC arise from benign and borderline precursors at the ovary and are not extra-ovarian metastases.
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