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Anna R. Poetsch et al.
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Mi Ni Huang et al.
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Moritz Schuette et al.
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Philip R. Davidson et al.
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Lucy R. Yates et al.
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Nicholas J. Haradhvala et al.
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Maria Secrier et al.
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Laura Broutier et al.
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Sandro Morganella et al.
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Sam Behjati et al.
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Carolina Negrei et al.
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Bernadett Szikriszt et al.
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Floriana Morgillo et al.
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Amelia M. Huehls et al.
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Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells
Tetsuya Suzuki et al.
GENES AND ENVIRONMENT (2016)
DNA repair in species with extreme lifespan differences
Sheila L. MacRae et al.
AGING-US (2015)
Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma
Karen D. Wright et al.
NEURO-ONCOLOGY (2015)
Gene essentiality and synthetic lethality in haploid human cells
Vincent A. Blomen et al.
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Chiara Focaccetti et al.
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Bettina Meier et al.
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Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation
Y. Fu et al.
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Michael I. Love et al.
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Signatures of mutational processes in human cancer
Ludmil B. Alexandrov et al.
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Christopher T. Saunders et al.
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Jared B. Parker et al.
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Amanda J. MacFarlane et al.
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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
Poulikos I. Poulikakos et al.
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Henrik Sahlin Pettersen et al.
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A flexible R package for nonnegative matrix factorization
Renaud Gaujoux et al.
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Amplification of thymidylate synthetase in metastatic colorectal cancer patients pretreated with 5-fluorouracil-based chemotherapy
Roshawn G. Watson et al.
EUROPEAN JOURNAL OF CANCER (2010)
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Valerie Boige et al.
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Somatic evolutionary genomics: Mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration
Steven A. Frank
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Beata G. Vertessy et al.
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Fast and accurate short read alignment with Burrows-Wheeler transform
Heng Li et al.
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5% 5-Fluorouracil Cream for Treatment of Verruca Vulgaris in Children
Julie Akiko Gladsjo et al.
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Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase η
Katsuhiko Hidaka et al.
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Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus
Katerina Dvorak et al.
GUT (2007)
5-fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity
Qian An et al.
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DB Longley et al.
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JL Grem
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Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
A de Gramont et al.
JOURNAL OF CLINICAL ONCOLOGY (2000)