期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-12319-x
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资金
- Programa de Apoyo a Centros con Financiamiento Basal from CONICYT - Comision Nacional de Investigacion Cientifica y Tecnologica de Chile [AFB 170004]
- Fondo Nacional de Desarrollo Cientifico y Tecnologico de Chile [FONDECYT 1171703]
- CONICYT
Tissue-resident memory CD8(+) T (Trm) cells mediate potent local innate and adaptive immune responses and play a central role against solid tumors. However, whether Trm cells cross-talk with dendritic cells (DCs) to support anti-tumor immunity remains unclear. Here we show that antigen-specific activation of skin Trm cells leads to maturation and migration to draining lymph nodes of cross-presenting dermal DCs. Tumor rejection mediated by Trm cells triggers the spread of cytotoxic CD8(+) T cell responses against tumor-derived neo- and self-antigens via dermal DCs. These responses suppress the growth of intradermal tumors and disseminated melanoma lacking the Trm cell-targeted epitope. Moreover, analysis of RNA sequencing data from human melanoma tumors reveals that enrichment of a Trm cell gene signature associates with DC activation and improved survival. This work unveils the ability of Trm cells to amplify the breath of cytotoxic CD8(+) T cell responses through DCs, thereby strengthening anti-tumor immunity.
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