相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium
Sabine Mueller et al.
INTERNATIONAL JOURNAL OF CANCER (2019)
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
Sudhir Chowdhry et al.
NATURE (2019)
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Parker L. Sulkowski et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
Alan Mackay et al.
CANCER CELL (2017)
The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity
Kensuke Tateishi et al.
CANCER RESEARCH (2017)
Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma
Surya Nagaraja et al.
CANCER CELL (2017)
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors
Sara Duarte-Pereira et al.
ONCOTARGET (2016)
Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice
Samuel A. J. Trammell et al.
SCIENTIFIC REPORTS (2016)
NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
Carles Canto et al.
CELL METABOLISM (2015)
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer
Deepak Sampath et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid
Jacqueline M. Tarrant et al.
TOXICOLOGY MECHANISMS AND METHODS (2015)
Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid
Jacqueline M. Tarrant et al.
TOXICOLOGY MECHANISMS AND METHODS (2015)
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction
Aidan G. Gilmartin et al.
NATURE CHEMICAL BIOLOGY (2014)
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
Gang Wu et al.
NATURE GENETICS (2014)
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
Kathryn R. Taylor et al.
NATURE GENETICS (2014)
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
Liwei Zhang et al.
NATURE GENETICS (2014)
Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes
Adam Blattler et al.
GENOME BIOLOGY (2014)
Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
Sebastian Bender et al.
CANCER CELL (2013)
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint
Petra Kleiblova et al.
JOURNAL OF CELL BIOLOGY (2013)
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2013)
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Jianjiong Gao et al.
SCIENCE SIGNALING (2013)
Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
Sevin Turcan et al.
ONCOTARGET (2013)
TARGETED, LCMS-BASED METABOLOMICS FOR QUANTITATIVE MEASUREMENT OF NAD+METABOLITES
Samuel A. J. Trammell et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2013)
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Sevin Turcan et al.
NATURE (2012)
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami et al.
CANCER DISCOVERY (2012)
Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software
Lee Kamentsky et al.
BIOINFORMATICS (2011)
A Preclinical Study on the Rescue of Normal Tissue by Nicotinic Acid in High-Dose Treatment with APO866, a Specific Nicotinamide Phosphoribosyltransferase Inhibitor
Uffe Hogh Olesen et al.
MOLECULAR CANCER THERAPEUTICS (2010)
PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas
David S. P. Tan et al.
CLINICAL CANCER RESEARCH (2009)
The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors
Mark Watson et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Nicotinic acid nicotinamide and nicotinamide riboside: A molecular evaluation of NAD(+) precursor vitamins in human nutrition
Katrina L. Bogan et al.
ANNUAL REVIEW OF NUTRITION (2008)
The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways
Xiongbin Lu et al.
CANCER AND METASTASIS REVIEWS (2008)
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner et al.
NATURE (2008)
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D
Robert C. Castellino et al.
JOURNAL OF NEURO-ONCOLOGY (2008)
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
Steen K. T. Ooi et al.
NATURE (2007)
Simultaneous mutation scanning and genotyping by high-resolution DNA melting analysis
Jesse Montgomery et al.
NATURE PROTOCOLS (2007)
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
P Bieganowski et al.
CELL (2004)
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
DV Bulavin et al.
NATURE GENETICS (2002)
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
J Li et al.
NATURE GENETICS (2002)