期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-11451-y
关键词
-
资金
- British Heart Foundation [SP/13/2/30111]
- Medical Research Council
- Public Health England [MR/L01341X/1]
- National Institute of Health Research Imperial Biomedical Research Centre
- National Institute of Health Research Health Protection Research Unit in Health Impact of Environmental Hazards [HPRU-2012-10141]
- UK Dementia Research Institute Ltd
- Alzheimer's Society
- Alzheimer's Research UK
- UK Medical Research Council
- Medical Research Council [MR/L01632X/1, MR/R0265051/1]
- Wellcome Trust Seed Award [206046/Z/17/Z]
- MRC [UKDRI-5001, MR/R026505/1] Funding Source: UKRI
- Wellcome Trust [206046/Z/17/Z] Funding Source: Wellcome Trust
Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over-represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据