期刊
JOURNAL OF FUNCTIONAL FOODS
卷 61, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2019.103497
关键词
Probiotics; Lactobacillus plantarum; Bile salt hydrolase; Cholesterol; Mechanism
资金
- Natural Science Foundation of Heilongjiang Province of China [C2016052]
- National High Technology Research and Development Program in China [2011AA100902]
- Open Research Fund for Key Laboratory of Dairy Science (Northeast Agricultural University), Ministry of Education, Heilongjiang Province, China [KLDS-18-003]
The present study aimed to evaluate bile salt hydrolase (BSH) activity and hypocholesterolemic effect of Lactobacillus plantarum KLDS 1.0344. BSH activity of the strain KLDS 1.0344 varied with different bile salts. High-cholesterol diet-induced male Sprague-Dawley rats were simultaneously administrated with strain KLDS 1.0344 for 4 weeks. The strain KLDS 1.0344 significantly improved lipid profiles in serum and liver, and increased fecal total cholesterol and total bile acids levels in high-cholesterol diet-fed rats (P < 0.05), and superior to L. rhamnosus GG. Moreover, expressions of genes related to cholesterol metabolism were regulated by the strain KLDS L0344, including down-regulation of hepatic HMGCR and FXR and intestinal NPC1L1, and up regulation of intestinal LXRa, ABCGS, ABCG8 and ABCA1 and hepatic CYP7A1 (P < 0.05). The hypocholeseterolemic effect of L. plantarum KLDS 1.0344 was modulated most likely by pathway of cholesterol absorption, synthesis, and catabolism, which might be partly due to its BSH activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据