期刊
VIRUSES-BASEL
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/v11100964
关键词
virus; broad-spectrum antiviral; antiviral agent; drug target; systems biology
类别
资金
- European Regional Development Fund, the Mobilitas Pluss Project [MOBTT39]
- National Research Foundation of Korea - Korea government (MSIP), Gyeonggi-do [NRF-2014K1A4A7A01074644]
- Jane and Aatos Erkko Foundation [170046]
- KISTI
- National Research Foundation of Korea [2014K1A4A7A01074644] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FLUAV), niclosamide against HSV-2, brequinar against human immunodeficiency virus 1 (HIV-1), and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vitro and in vivo tests.
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