期刊
BIOTECHNOLOGY JOURNAL
卷 11, 期 5, 页码 642-647出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201500544
关键词
Cell activation; Cell death; Extracellular vesicles (EV) concentration; Industrial bioprocess; Microenvironment
资金
- European Union's Seventh Framework Programme [289253]
- Erasmus traineeship plus program
- Clariant Produkte (Deutschland) GmbH
The application of Candida antarctica lipase B in enzyme-catalyzed synthesis of aromatic-aliphatic oligoesters is here reported. The aim of the present study is to systematically investigate the most favorable conditions for the enzyme catalyzed synthesis of aromatic-aliphatic oligomers using commercially available monomers. Reaction conditions and enzyme selectivity for polymerization of various commercially available monomers were considered using different inactivated/activated aromatic monomers combined with linear polyols ranging from C-2 to C-12. The effect of various reaction solvents in enzymatic polymerization was assessed and toluene allowed to achieve the highest conversions for the reaction of dimethyl isophthalate with 1,4-butanediol and with 1,10-decanediol (88 and 87% monomer conversion respectively). M-w as high as 1512 Da was obtained from the reaction of dimethyl isophthalate with 1,10-decanediol. The obtained oligomers have potential applications as raw materials in personal and home care formulations, for the production of aliphatic-aromatic block co-polymers or can be further functionalized with various moieties for a subsequent photo- or radical polymerization.
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