期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 21, 期 5, 页码 368-382出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2019.1671609
关键词
Dopamine receptor availability; hyperdopaminergia; neurometabolic coupling; thalamus; cerebellum
类别
资金
- Kettering Health Network Foundation
- United States Air Force, Air Force Research Laboratory (AFRL/HEOP), Air Force Materiel Command [F33615-98-26002]
Objectives: Overlapping decreases in extrastriatal dopamine D-2/D-3-receptor availability and glucose metabolism have been reported in subjects with schizophrenia. It remains unknown whether these findings are physiologically related or coincidental. Methods: To ascertain this, we used two consecutive F-18-fluorodeoxyglucose and F-18-fallypride positron emission tomography scans in 19 healthy and 25 unmedicated schizophrenia subjects. Matrices of correlations between F-18-fluorodeoxyglucose uptake and F-18-fallypride binding in voxels at the same xyz location and AFNI-generated regions of interest were evaluated in both diagnostic groups. Results: F-18-fluorodeoxyglucose uptake and F-18-fallypride binding potential were predominantly positively correlated across the striatal and extrastriatal grey matter in both healthy and schizophrenia subjects. In comparison to healthy subjects, significantly weaker correlations in subjects with schizophrenia were confirmed in the right cingulate gyrus and thalamus, including the mediodorsal, lateral dorsal, anterior, and midline nuclei. Schizophrenia subjects showed decreased D-2/D-3-receptor availability in the hypothalamus, mamillary bodies, thalamus and several thalamic nuclei, and increased glucose uptake in three lobules of the cerebellar vermis. Conclusions: Dopaminergic system may be involved in modulation of grey matter metabolism and neurometabolic coupling in both healthy human brain and psychopathology. Hyperdopaminergic state in untreated schizophrenia may at least partly account for the corresponding decreases in grey matter metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据