期刊
BIOTECHNOLOGY AND BIOENGINEERING
卷 114, 期 4, 页码 717-739出版社
WILEY
DOI: 10.1002/bit.26182
关键词
osteoarthritis; articular cartilage; biomaterials; scaffolds; regeneration; viscosupplementation; gene therapy; tissue engineering
资金
- EU Marie Curie ITN MultiScaleHuman: Multi-Scale Biological Modalities for Physiological Human Articulation [MRTN-CT-2011-289897]
- ARTICULATE-Desenvolvimento de novos produtos e terapias regenerativas para o tratamento de patologias articulares [NORTE-07-0202-FEDER-023189]
- Portuguese Foundation for Science and Technology (FCT) [Investigador FCT 2012 (IF/00423/2012)]
Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2017;114: 717-739. (c) 2016 Wiley Periodicals, Inc.
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