期刊
TRENDS IN NEUROSCIENCES
卷 42, 期 10, 页码 693-708出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2019.08.005
关键词
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资金
- Human Frontier Science Program [RGP0045/2018]
- National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health [R01GM118530]
- National Science Foundation [1845734]
- National Institute of Neurological Disorders and Stroke (NINDS) [F31NS110301]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1845734] Funding Source: National Science Foundation
Neurons require unique subcellular compartmentalization to function efficiently. Formed from proteins and RNAs through liquid-liquid phase separation, membraneless organelles (MLOs) have emerged as one way in which cells form distinct, specialized compartments in the absence of lipid membranes. We first discuss MLOs that are common to many cell types as well as those that are specific to neurons. Interestingly, many proteins associated with neurodegenerative disease are found in MLOs, particularly in stress and transport granules. We next review possible links between neurodegeneration and MLOs, and the hypothesis that the protein and RNA inclusions formed in disease are related to the functional complexes occurring inside these MLOs. Finally, we discuss the hypothesis that protein post-translational modifications (PTMs), which can alter phase separation, can modulate MLO formation and provide potential new therapeutic strategies for currently untreatable neurodegenerative diseases.
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