期刊
TRENDS IN MICROBIOLOGY
卷 28, 期 2, 页码 95-108出版社
CELL PRESS
DOI: 10.1016/j.tim.2019.09.004
关键词
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资金
- National Institutes of Health [NIH R01 GM118475]
- Host Microbiome Initiative at the University of Michigan Medical School
Starch is a polymer of glucose and is one of the most abundant carbohydrates in a Western diet. Resistant starch escapes digestion by host small intestinal glucoamylases and transits the colon where it is degraded by the combined efforts of many gut bacteria. Bacterial metabolism and fermentation of resistant starch leads to increases in short-chain fatty acids, including the clinically beneficial butyrate. Here, we review the molecular machinery that gut bacteria use to degrade starch and how these functions may intersect to facilitate complete starch digestion. While the protein complexes that gut bacteria use to degrade starch differ across phyla, some molecular details converge to promote the optimal positioning of enzymes and substrate for starch degradation.
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