期刊
TRENDS IN IMMUNOLOGY
卷 40, 期 11, 页码 1035-1052出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.09.005
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资金
- Terrell International Undergraduate Scholarship from the Australian National University
- Joyce Fildes Honours Scholarship from The John Curtin School of Medical Research
- Australian National University
- Gretel and Gordon Bootes Medical Research Foundation
- National Health and Medical Research Council of Australia [APP1141504, APP1146864, APP1162103, APP1163358]
- R.D. Wright Career Development Fellowship [APP1162025]
The inflammasome is a cytosolic immune signaling complex that induces inflammation and pyroptosis. lnflammasome complexes respond to a variety of pathogens, as well as danger or homeo stasis-altering signals; they can play critical roles in the development of autoinfiammatory conditions and cancer. Studies have now provided additional insights into the activation mechanisms and regulation of established inflammasome complexes, including NLRP1b, NLRP3, NOD-like receptor family apoptosis inhibitory protein (NAIP)-NLRC4, absent in melanoma (AIM)2, caspase-11, and pyrin. New activators and regulators of emerging NLRP6 and NLRP9b inflammasome complexes have also been described. We highlight the latest progress in our understanding of the molecular mechanisms governing inflammasome activation and pyroptosis, including the discovery of the pore-forming protein gasdermin D (GSDMD). We also discuss the importance of inflammasome activators and regulators in health and disease.
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