期刊
TRENDS IN BIOTECHNOLOGY
卷 38, 期 3, 页码 316-333出版社
CELL PRESS
DOI: 10.1016/j.tibtech.2019.09.007
关键词
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资金
- BBSRC DTP [BB/M011208/1]
- BBSRC David Phillips Fellowship [BB/K014773/1]
- BBSRC [BB/K014773/1, 1618786, BB/M011208/1] Funding Source: UKRI
Insights from novel mechanistic paradigms in gene expression control have led to the development of new gene expression systems for bioproduction, control, and sensing applications. Coupled with a greater understanding of synthetic burden and modern creative biodesign approaches, contemporary bacterial gene expression tools and systems are emerging that permit fine-tuning of expression, enabling greater predictability and maximisation of specific productivity, while minimising deleterious effects upon cell viability. These advances have been achieved by using a plethora of regulatory tools, operating at all levels of the so-called 'central dogma' of molecular biology. In this review, we discuss these gene regulation tools in the context of their design, prototyping, integration into expression systems, and biotechnological application.
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