期刊
BIOTECHNOLOGY ADVANCES
卷 34, 期 3, 页码 305-320出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2016.02.008
关键词
Cardiovascular diseases (CVDs); Point-of-care testing (POCT); Microfluidics; Nanotechnology; Paper-based diagnostics; Mobile health
资金
- National Natural Science Foundation of China [11372243, 11532009, 11522219]
- National 111 Project of China [B06024]
- International Science AMP
- Technology Cooperation Program of China [2013DFG02930]
- National Instrumentation Program [2013YQ190467]
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [11372243, 11532009, 11522219]
- National 111 Project of China [B06024]
- International Science AMP
- Technology Cooperation Program of China [2013DFG02930]
- National Instrumentation Program [2013YQ190467]
- Fundamental Research Funds for the Central Universities
Cardiovascular diseases (CVDs) are the main causes of morbidity and mortality in the world where about 4 in every 5 CVD deaths happen in low- and middle-income countries (LMICs). Most CVDs are preventable and curable, which is largely dependent on timely and effective interventions, including diagnosis, prognosis and therapeutic monitoring. However, these interventions are high-cost in high income countries and are usually lacking in LMICs. Thanks to the rapid development of microfluidics and nanotechnology, lots of portable analytical devices are developed for detection of CVDs at the point-of-care (POC). In the meantime, smartphone, as a versatile and powerful handheld tool, has been employed not only as a reader for microfluidic assays, but also as an analyzer for physiological indexes. In this review, we present a comprehensive introduction of the current status and potential development direction on POC diagnostics for CVDs. First of all, we introduce some main facts about CVDs and their standard diagnostic procedures and methods. Second, we discuss about both commercially available POC devices and developed prototypes for detection of CVDs via immunoassays. Subsequently, we report the advances in smartphone-based readout for microfluidic assays. Finally, we present some examples using smartphone, individually or combined with other components or devices, for CVD monitoring. We envision an integrated smartphone-based system capable of functioning blood tests, disease examination, and imaging will come in the future. (C) 2016 Elsevier Inc All rights reserved.
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