期刊
BIOTECHNOLOGY ADVANCES
卷 34, 期 8, 页码 1275-1288出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2016.09.003
关键词
Infectious diseases; Nanotechnology; Diagnostic tools; Point-of-care (POC); Pathogens
资金
- National University of Singapore, Department of Pharmacy ((AcRF) Tier 1-FRC [R-148-000-164-112, R-148-000-213-112]
- NUSAGE grant [N-148-000-009-001]
- MOE of Singapore [MOE2009-T2-2-011, R-398-000-068-112]
- A-STAR-SERC [R-148-000-222-305]
- Leung Kai Fook grant [R-148-000-227-720]
Nanotechnology has gained much attention over the last decades, as it offers unique opportunities for the advancement of the next generation of sensing tools. Point-of-care (POC) devices for the selective detection of biomolecules using engineered nanoparticles have become a main research thrust in the diagnostic field. This review presents an overview on how the POC-associated nanotechnology, currently applied for the identification of nucleic acids, proteins and antibodies, might be further exploited for the detection of infectious pathogens: although still premature, future integrations of nanoparticles with biological markers that target specific microorganisms will enable timely therapeutic intervention against life-threatening infectious diseases. (C) 2016 Published by Elsevier Inc.
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