4.4 Article

18O-Labeled chiral compounds enable the facile determination of enantioselectivity by mass spectroscopy

期刊

TETRAHEDRON LETTERS
卷 61, 期 2, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.151367

关键词

O-18-labeled chiral compound; Enantioselectivity; Mass spectroscopy; Enzyme-catalyzed kinetic resolution; Determination method of enantiomeric excess

资金

  1. MEXT [15H05849]
  2. AMED [18061567]
  3. Japan Science and Technology Agency's (JST) A-step program [18067420]
  4. Japan Science and Technology Agency's (JST) CREST
  5. Ogasawara Foundation for the Promotion of Science Engineering
  6. [26288049]
  7. [26220804]
  8. [25220913]
  9. [17865428]

向作者/读者索取更多资源

The synthesis of O-18-labeled enantioenriched compounds and their facile evaluation system to determine enantiomeric excess (ee) using mass spectroscopy was described. Equimolar mixture of O-18-labeled and non-labeled pseudo-enantiomers were used as a substrate for enzyme-catalyzed kinetic resolution. Ees determined by mass spectroscopy showed good agreement with those by HPLC. Our method would be a promising tool for fast evaluation of ee and contribute to development of enantioselective transformations. (C) 2019 Published by Elsevier Ltd.

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