期刊
TETRAHEDRON LETTERS
卷 61, 期 2, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.151367
关键词
O-18-labeled chiral compound; Enantioselectivity; Mass spectroscopy; Enzyme-catalyzed kinetic resolution; Determination method of enantiomeric excess
资金
- MEXT [15H05849]
- AMED [18061567]
- Japan Science and Technology Agency's (JST) A-step program [18067420]
- Japan Science and Technology Agency's (JST) CREST
- Ogasawara Foundation for the Promotion of Science Engineering
- [26288049]
- [26220804]
- [25220913]
- [17865428]
The synthesis of O-18-labeled enantioenriched compounds and their facile evaluation system to determine enantiomeric excess (ee) using mass spectroscopy was described. Equimolar mixture of O-18-labeled and non-labeled pseudo-enantiomers were used as a substrate for enzyme-catalyzed kinetic resolution. Ees determined by mass spectroscopy showed good agreement with those by HPLC. Our method would be a promising tool for fast evaluation of ee and contribute to development of enantioselective transformations. (C) 2019 Published by Elsevier Ltd.
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