Sequential decarboxylative [3+2] cycloaddition and Staudinger/aza-Wittig reactions for diastereoselective synthesis of tetrahydro-pyrroloquinazolines and tetrahedro-pyrrolobenzodiazepines

A method for diastereoselective synthesis of tetrahydro-pyrroloquinazolines and tetrahydro-pyrrolobenzodiazepines is developed through sequential reactions including decarboxylative 1,3-dipolar cycloaddition of non-stabilized azomethine ylides, N-acylation or N-alkylation, and the Staudinger/aza-Wittig reactions. (C) 2019 Published by Elsevier Ltd.