期刊
TETRAHEDRON LETTERS
卷 60, 期 40, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.151108
关键词
Ureas; N-Oxides; Dialkylcyanamides; C-H activation
资金
- Russian Science Foundation [19-13-00008]
- Russian Foundation for Basic Research [19-33-50034]
- Saint Petersburg State University
- Russian Science Foundation [19-13-00008] Funding Source: Russian Science Foundation
Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C-H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as lead-like scaffolds for medicinal chemistry. Atom-economy, environmental friendliness (no halide-containing or toxic reagents), simple work-up, as well as scalability are the main advantages of the employed procedure. (C) 2019 Elsevier Ltd. All rights reserved.
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