期刊
TETRAHEDRON LETTERS
卷 60, 期 40, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.151104
关键词
Thiomorpholine; Thiomorpholine 1,1-dioxide; Enantioselective; Organocatalysis
资金
- William K. Warren Family and Foundation
- Chair in Medicine
In the course of our drug discovery programs, we had need to access chiral, 2-substituted thiomorpholines and their oxidized congeners, thiomorpholine 1,1-dioxides. Here, we disclose a high-yielding, general protocol for the enantioselective synthesis of C2-functionalized thiomorpholines and thiomorpholine 1,1-dioxides. (C) 2019 Elsevier Ltd. All rights reserved.
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