期刊
SYNTHESIS-STUTTGART
卷 52, 期 4, 页码 619-628出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0039-1691069
关键词
xanthones; coupling; microwave-assisted synthesis; palladium nanoparticles; green biochar
资金
- National Council of Scientific and Technical Research (Consejo Nacional de Investigaciones Cientificas y Tecnicas
- CONICET), Argentina
- National Agency for Scientific and Technological Promotion (Agencia Nacional de Promocion Cientifica y Tecnologica
- ANPCyT), Argentina
- Universidad Nacional del Sur (Secretaria General de Ciencia y Tecnologia, Universidad Nacional del Sur
- SGCyT-UNS), Argentina
- CONICET
- ANPCyT
We report an efficient, selective, rapid and eco-friendly protocol for the one-step synthesis of a small xanthone library via an intermolecular catalytic coupling from readily available salicylaldehydes and 1,2-dihaloarenes under ligand-free conditions. To achieve this advantageous direct annulation, we used a novel recoverable palladium nanocatalyst supported on a green biochar under microwave irradiation. Unlike other existing palladium-based approaches, our synthetic strategy showed a greater operational simplicity, drastic reduction in reaction times, and an excellent tolerance to diverse functional groups. The reaction proceeds in very good yields and with high regioselectivity. The novel heterogeneous catalyst can be recycled and reused up to four times without significant loss of activity.
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