期刊
SMALL
卷 15, 期 50, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201905209
关键词
bidirectional transport; bio-conveyor belts; evanescent waves; fiber probes
类别
资金
- National Natural Science Foundation of China [11904134, 61905092, 11874183, 61827822, 11774135]
- Start-up Fund of Natural Science Foundation of Guangdong Province [2018A030310501]
- Science and Technology Program of Guangzhou [201904010411]
- Fundamental Research Funds for the Central Universities [21618301, 11619321]
The bidirectional transport of nanoparticles and biological cells is of great significance in efficient biological assays and precision cell screening, and can be achieved with optical conveyor belts in a noncontact and noninvasive manner. However, implantation of these belts into biological systems can present significant challenges owing to the incompatibility of the artificial materials. In this work, an optical conveyor belt assembled from natural biological cells is proposed. The diameter of the belt (500 nm) is smaller than the laser wavelength (980 nm) and, therefore, the evanescent wave stably traps the nanoparticles and cells on the belt surface. By adjusting the relative power of the lasers injected into the belt, the particles or cells can be bidirectionally transported along the bio-conveyor belt. The experimental results are numerically interpreted and the transport velocities are investigated based on simulations. Further experiments show that the bio-conveyor belt can also be assembled with mammalian cells and then applied to dynamic cell transport in vivo. The bio-conveyor belt might provide a noninvasive and biocompatible tool for biomedical assays, drug delivery, and biological nanoarchitectonics.
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